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Melanotan II is a synthetic cyclic heptapeptide analog of α-melanocyte-stimulating hormone (α-MSH). It has been studied in preclinical and early clinical research for its activity at melanocortin receptors (primarily MC1R and MC4R), which are involved in pigmentation signaling, energy homeostasis, and neuroendocrine pathways.
In laboratory models, Melanotan II has been evaluated for receptor-mediated effects on melanogenesis and appetite-related signaling pathways.
Structure: Cyclic heptapeptide (lactam bridge–stabilized)
Peptide Sequence: Ac-Nle-c[Asp-His-D-Phe-Arg-Trp-Lys]-NH₂
Molecular Formula: C₅₀H₆₉N₁₅O₉
