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MOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA-c) is a mitochondria-derived peptide encoded within mitochondrial DNA. It has been studied in preclinical and early clinical research for its role in metabolic regulation, cellular stress response, and mitochondrial signaling pathways.
In laboratory models, MOTS-c has been investigated for its interaction with AMPK activation, insulin sensitivity modulation, and adaptive metabolic responses under conditions of cellular stress.
Structure: 16 amino acid mitochondrial-derived peptide
Peptide Sequence: Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg
Molecular Formula: C₁₀₁H₁₅₂N₂₈O₂₂S₂
