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Semax is a synthetic heptapeptide engineered from the active fragment of adrenocorticotropic hormone (ACTH 4–10), designed to deliver enhanced stability and targeted neuroactive properties in research applications. This compound is widely utilized in neurobiology and cognitive research for its ability to modulate key signaling pathways associated with neuronal plasticity, stress adaptation, and neurotransmitter regulation. Studies indicate that Semax may influence BDNF expression, while interacting with dopaminergic and serotonergic systems—making it a valuable tool in experimental models focused on cognition, mood, and central nervous system function.
From a molecular standpoint, Semax is defined by the sequence:
Met–Glu–His–Phe–Pro–Gly–Pro (MEHFPGP)
This precise arrangement of amino acids contributes to its resistance to rapid enzymatic degradation compared to native ACTH fragments, allowing for more consistent performance in controlled research environments.
Molecular Formula: C₃₇H₅₁N₉O₁₀S
Molecular Weight: ~813.9 g/mol
